Early-stage folding in proteins (in silico) sequence-to-structure relation

TitleEarly-stage folding in proteins (in silico) sequence-to-structure relation
Publication TypeJournal Article
Year of Publication2005
AuthorsBrylinski M, Konieczny L, Czerwonko P, Jurkowski W, Roterman I
JournalJ Biomed Biotechnol
Volume2005
Issue2
Pagination65-79
Date Published2005 Jun 30
ISSN1110-7243
Abstract

A sequence-to-structure library has been created based on the complete PDB database. The tetrapeptide was selected as a unit representing a well-defined structural motif. Seven structural forms were introduced for structure classification. The early-stage folding conformations were used as the objects for structure analysis and classification. The degree of determinability was estimated for the sequence-to-structure and structure-to-sequence relations. Probability calculus and informational entropy were applied for quantitative estimation of the mutual relation between them. The structural motifs representing different forms of loops and bends were found to favor particular sequences in structure-to-sequence analysis.

Alternate JournalJournal of Biomedicine & Biotechnology
Full Text

iPaper

PreviewAttachmentSize
2005_jbb.pdf1.91 MB

© Michal Brylinski
This website is hosted at the CCT