eVolver Webserver

eVolver is an optimization engine that evolves protein sequences to stabilize the respective structures by a variety of potentials, which are compatible with those commonly used in protein threading. The scoring function combines several energy terms: a burial potential, secondary structure preferences, a distant-dependent contact potential, sequence profiles and anti-bunching restraints.
If you use eVolver, please cite the following papers:

eVolver is also available as a standalone software distribution. Datasets are available for download from here. See the manual for the details on the output file format.

eVolver is free of charge under the terms of GNU General Public License for non-commercial use. It is distributed without any warranty, but with best wishes.

This server is running eVolver v1.0. Click here to see some sample results.


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3-10 alphanumerical characters.


Single chain in PDB format, 50-600 residues.


Protein library used to build structure-based profiles. See manual for explanations.


Select the initial sequence that will be used as a starting point in Simulated Annealing.


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© Michal Brylinski
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