Ligation site in proteins recognized in silico

TitleLigation site in proteins recognized in silico
Publication TypeJournal Article
Year of Publication2006
AuthorsBrylinski M, Konieczny L, Roterman I
JournalBioinformation
Volume1
Issue4
Pagination127-9
Date Published2006
ISSN0973-2063
Abstract

Recognition of a ligation site in a protein molecule is important for identifying its biological activity. The model for in silico recognition of ligation sites in proteins is presented. The idealized hydrophobic core stabilizing protein structure is represented by a three-dimensional Gaussian function. The experimentally observed distribution of hydrophobicity compared with the theoretical distribution reveals differences. The area of high differences indicates the ligation site. AVAILABILITY: http://bioinformatics.cm-uj.krakow.pl/activesite.

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